pentobarbital will reduce the extent or impact of hydrocortisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will reduce the extent or outcome of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is usually a sensitive CYP3A4 substrate. Coadministration w… Read More